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Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine |
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| Authors: | Crispin Hiley Elza C de Bruin Nicholas McGranahan Charles Swanton |
| Affiliation: | .Cancer Research UK London Research Institute, Lincoln’s Inn Fields, London, WC2A 3LY UK ;.Institute of Cancer Research, Old Brompton Road, London, SW7 3RP UK ;.University College London Cancer Institute, Huntley Street, London, WC1E 6BT UK ;.Centre for Mathematics & Physics in the Life Science & Experimental Biology (CoMPLEX), University College London, Gower Street, London, WC1E 6BT UK |
| Abstract: | The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design. |
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