NLRP3 polymorphism is associated with protection against human
T-lymphotropic virus 1 infection |
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| Authors: | Anselmo Jiro Kamada Alessandra Pontillo Rafael Lima Guimar?es Paula Loureiro Sergio Crovella Lucas André Cavalcanti Brand?o |
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| Institution: | 1. Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil;2. Laboratório de Imunogenética, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil;3. Fundação de Hematologia e Hemoterapia de Pernambuco, Recife, PE, Brasil;4. Departamento de Patologia, Universidade Federal de Pernambuco, Recife, PE, Brasil |
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| Abstract: | Inter-individual heterogeneity in the response to human T-lymphotropic virus 1
(HTLV-1) infection has been partially attributed to host genetic background. The
antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular
patterns and regulates immune responses via the activation of
interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between
polymorphisms in the inflammasome receptors NLRP1 and
NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian
population (84 HTLV-1 carriers and 155 healthy controls). NLRP3
rs10754558 G/G was associated with protection against HTLV-1 infection (p =
0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability;
therefore, our results suggest that higher NLRP3 expression may augment first-line
defences, leading to the effective protection against HTLV-1 infection. |
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| Keywords: | NLRP3 NLRP1 single nucleotide polymorphisms innate immunity HTLV-1 |
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