Effect of <Emphasis Type="Italic">Porphyromonas gingivalis</Emphasis> Vesicles on Coaggregation of <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> to Oral Microorganisms |
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| Authors: | Arihide Kamaguchi Koji Nakayama Satoshi Ichiyama Reiko Nakamura Toshihiro Watanabe Michio Ohta Hisae Baba Tohru Ohyama |
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| Institution: | (1) Department of Oral Microbiology, School of Dentistry, Health Sciences University of Hokkaido, Toubetu 061-0293, Japan;(2) Division of Microbiology and Oral Infection, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan;(3) Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;(4) Department of Food Science and Technology, Faculty of Bioindustry, Tokyo University of Agriculture, Abashiri 099-2493, Japan;(5) Department of Molecular Bacteriology, Nagoya University Graduate School of Medicine, Tsurumi 65, Showa-Ku, Nagoya 466-8550, Japan |
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| Abstract: | Vesicles from the outer membrane of Porphyromonas gingivalis have the ability to aggregate a wide range of Streptococcus spp., Fusobacterium nucleatum, Actinomyces naeslundii, and Actinomyces viscosus. We found that in the presence of P. gingivalis vesicles, Staphylococcus aureus coaggregated with Streptococcus spp., and the mycelium-type Candida albicans, but not the yeast type. Autoaggregation of S. aureus in the presence of P. gingivalis vesicles is inhibited by L-arginine, L-lysine, and L-cysteine. Both the methicillin-sensitive (MSSA) and -resistant (MRSA) strains of S. aureus were able to coaggregate with Streptococcus spp., A. naeslundii, and A. viscosus when they were treated with P. gingivalis vesicles. P. gingivalis vesicle-treated mycelium-type C. albicans coaggregated with S. aureus, but the yeast-type did not. These results indicate that strains of S. aureus, including MRSA, could adhere to oral biofilms in dental plaque on the tooth surface or in the gingival crevice when P. gingivalis is present. |
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