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Effect of membrane moiety and magnesium ions on the inhibition of matrix-induced alkaline phosphatase by zinc ions
Authors:P Ciancaglini  J M Pizauro  C Curti  A C Tedesco  F A Leone
Affiliation:1. Departamento de Quimica, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto-USP, 14049 Ribeirão Preto, SP. Brasil [Tel. 634-6255];2. Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinárias-UNESP, 14870 Jaboticabal, SP. Brasil;3. Departamento de Fisica e Química, Faculdade de Ciências Farmaceuticas-USP, 14049 Ribeirão Preto, SP. Brasil;1. Eawag, Swiss Federal Institute of Aquatic Science and Technology, CH-8600 Dübendorf, Switzerland;2. Curtin Water Quality Research Centre, Curtin University, GPO Box U1987, Perth, WA 6845, Australia;3. Université Lille 1 Sciences and Technologies, LASIR, UMR CNRS 8516, 59655 Villeneuve d''Ascq, France;4. Departamento de Ingeniería Química y Química Física, Universidad de Extremadura, Avda. Elvas s/n, 06006 Badajoz, Spain;5. School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland;6. Institute of Biogeochemistry and Pollutant Dynamics, ETH Zürich, CH-8092 Zürich, Switzerland;1. School of Earth, Atmospheric and Environmental Sciences and Williamson Research Centre for Molecular Environmental Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK;2. Scottish Universities Environmental Research Centre, East Kilbride G75 0QF, UK;3. NERC Radiocarbon Facility, East Kilbride G75 OQF, UK;4. Department of Earth Sciences, University of Oxford, South Parks Road, OX1 3AN Oxford, UK
Abstract:1. The inhibition of matrix-induced alkaline phosphatase by zinc ions is due to the displacement of magnesium ions from its binding site. 2. Binding of magnesium ions to alkaline phosphatase induces conformational changes which activate the enzyme. 3. Binding of zinc ions to alkaline phosphatase induces conformational changes which impair the catalytic action of the enzyme. 4. The inhibition of the enzyme by zinc ions is affected by membrane environment and magnesium ions.
Keywords:
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