Opioid system and cardiac resistance to ischemic and reperfusion injuries |
| |
| Authors: | Lishmanov Iu B Maslov L N Tam S V Bogomaz S A |
| |
| Institution: | Research Institute of Cardiology, Siberian Branch of the Russian Acad. Med. Sci., Tomsk. |
| |
| Abstract: | In vivo pre-treatment with the opioid receptor antagonist D,L-naloxone completely eliminated the reperfusion-induced creatine kinase (CK) leakage from the rat isolated perfused haert. The inactive isomer L-naloxone decreased the CK release by half. The (-antagonist ICI 174,864 and k-antagonist nor-binanltorphimine exerted a weaker protective effect. The (-antagonist DAMGO, the (2-agonist DSLET, the k1-agonist spiradolin, or the sigma-agonist (+)-SKF 10047, improved myocardial cell viability after ischemia/reperfusion. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
