A Study of Cytological Changes in the Bone Marrow of Patients with Severe Fever with Thrombocytopenia Syndrome |
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| Authors: | Xing QuanTai Chen FengZhe Song XiuGuang Chen DongGe |
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| Institution: | 1. Department of Infectious Diseases , Qilu Hospital of Shandong University, Jinan, China.; 2. Infectious Diseases Hospital of Jinan, Jinan, China.; 3. Department of Blood Laboratory, Qilu Hospital of Shandong University, Jinan, China.; Rutgers - New Jersey Medical School, United States of America, |
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| Abstract: | BackgroundPeripheral blood leucopenia and thrombocytopenia are the main manifestations in severe fever with thrombocytopenia syndrome (SFTS) patients. However, the underlying causes are poorly understood. Therefore, we aimed to investigate cytology of bone marrow samples collected from SFTS patients. Methods10 SFTS patients were identified by typical clinical manifestations, detection of peripheral blood leucopenia and thrombocytopenia, and nucleic acid-based detection of the newly identified bunyavirus. SFTS patients, along with 10 participants with acute aplastic anemia and 10 healthy volunteers were enrolled in this study after written informed consent to undergo bone marrow cytological examination.ResultsWe observed similar bone marrow properties in SFTS patients and healthy volunteers, significantly different from the characteristics observed in acute aplastic anemia patients.ConclusionSimilarities between bone marrow samples collected from SFTS patients and healthy volunteers suggest that peripheral blood leucopenia and thrombocytopenia do not result from bone marrow cell plasticity. |
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