Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible |
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| Authors: | Juraj Bosák Lenka Micenková Martin Vrba Alena ?ev?íková Daniela Dědi?ová Debora Garzetti David ?majs |
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| Institution: | 1. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; 2. Department of Clinical Microbiology, University Hospital Brno, Brno, Czech Republic.; 3. National Reference Laboratory for Salmonella, The National Institute of Public Health, Prague, Czech Republic.; 4. Max von Pettenkofer-Institute, Ludwig Maximilian University of Munich, Munich, Germany.; Centre National de la Recherche Scientifique, Aix-Marseille Université, France, |
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| Abstract: | Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY. |
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