Sequence analysis,structure and binding site prediction of Sigma 1 receptor protein by in silico method |
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Authors: | Narayanasamy Lokeswaran Latha Garimella Gyananath Pudukulathan Kader Zubaidha |
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Institution: | 1.School of Life Sciences, S. R. T. M. University, Nanded - 431606, India;2.Chemical Sciences, S. R. T. M. University, Nanded-431606, India |
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Abstract: | Sigma 1 Receptor is a subtype of opioid receptor that participates in membrane remodeling and cellular differentiation in the
nervous system. Sigma1 Receptor protein with amino acid length ranging from 229 is widely distributed in the liver and
moderately in the intestine, kidney, white pulp of the spleen, adrenal gland, brain, placenta and the lung. In this study, the three
dimensional structure for sigma 1 receptor protein has been developed by in- silico analysis based on evolutionary trace analysis of
37 sigma proteins from different sources. The present work focus on identification of functionally important residues and its
interaction with antipsychotic drugs reported in literature. |
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Keywords: | Sigma receptor Evolutionary trace Binding sites |
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