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In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12 |
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| Authors: | Chen Tzu Yu Hale John D F Tagg John R Jain Rohit Voss Abigail L Mills Nikki Best Emma J Stevenson Duncan S Bird Philip A Walls Tony |
| Institution: | 1.Department of Otolaryngology, Head and Neck Surgery, Christchurch Public Hospital, Christchurch, New Zealand ;2.Blis Technologies Ltd, Dunedin, New Zealand ;3.Department of Paediatric Otolaryngology, Starship Children’s Hospital, Auckland, New Zealand ;4.Department of Paediatrics and Child Health, University of Auckland, Auckland, New Zealand ;5.Department of Surgery, University of Otago, Christchurch, New Zealand ;6.Department of Paediatrics, University of Otago, Christchurch, New Zealand ; |
| Abstract: | Otitis media is a common childhood infection, frequently requiring antibiotics. With high rates of antibiotic prescribing and increasing antibiotic resistance, new strategies in otitis media prevention and treatment are needed. The aim of this study was to assess the in vitro inhibitory activity Streptococcus salivarius BLIS K12 against otitis media pathogens. Efficacy of the bacteriocin activity of S. salivarius BLIS K12 against the otitis media isolates was assessed using the deferred antagonism test. Overall, 48% of pathogenic isolates exhibited some growth inhibition by S. salivarius BLIS K12. S. salivarius BLIS K12 can inhibit the in vitro growth of the most common pathogens. |
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