Absence of Auditory M100 Source Asymmetry in Schizophrenia and Bipolar Disorder: A MEG Study |
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| Authors: | Ying Wang Yigang Feng Yanbin Jia Yanping Xie Wensheng Wang Yufang Guan Shuming Zhong Dan Zhu Li Huang |
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| Institution: | 1. Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.; 2. Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou, China.; 3. Medical Imaging Center, Guangdong 999 Brain Hospital, Guangzhou, China.; 4. Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China.; VU University Medical Center, Netherlands, |
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| Abstract: | BackgroundWhether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry. Several studies have demonstrated anomalous structural and functional superior temporal gyrus (STG) symmetries in schizophrenia. We examined bipolar patients to determine if they also have altered STG asymmetry.MethodsWhole-head magnetoencephalography (MEG) recordings of auditory evoked fields were obtained for 20 subjects with schizophrenia, 20 with bipolar disorder, and 20 control subjects. Neural generators of the M100 auditory response were modeled using a single equivalent current dipole for each hemisphere. The source location of the M100 response was used as a measure of functional STG asymmetry. ResultsControl subjects showed the typical M100 asymmetrical pattern with more anterior sources in the right STG. In contrast, both schizophrenia and bipolar disorder patients displayed a symmetrical M100 source pattern. There was no significant difference in the M100 latency and strength in bilateral hemispheres within three groups.ConclusionsOur results indicate that disturbed asymmetry of temporal lobe function may reflect a common deviance present in schizophrenia and bipolar disorder, suggesting the two disorders might share etiological and pathophysiological factors. |
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