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Milk Fermented by Lactobacillus paracasei NCC 2461 (ST11) Modulates the Immune Response and Microbiota to Exert its Protective Effects Against Salmonella typhimurium Infection in Mice |
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| Authors: | Acurcio Leonardo Borges Wuyts Sander de Cicco Sandes Sávio Henrique Sant’anna Felipe Machado Pedroso Silvia Helena Sousa Pietra Bastos Rafael Wesley dos Reis Diego Carlos Vieira Andréa Faria Cassali Geovanni Dantas Lebeer Sarah de Souza Marcelo Resende Nicoli Jacques Robert |
| Institution: | 1.Department of Veterinary Medicine, Formiga University Center (UNIFOR-MG), Av. Dr. Arnaldo de Senna, 328, Água Vermelha, Formiga, MG, 35574-530, Brazil ;2.Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium ;3.Department of General Biology, ICB, UFMG, Belo Horizonte, MG, Brazil ;4.Department of Meat and Dairy Products Technology and Inspection, Veterinary School (EV), Federal University of Minas Gerais, Belo Horizonte, MG, Brazil ;5.Department of Microbiology, Biological Science Institute (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil ;6.Faculty of Pharmaceutical Sciences from Ribeirão Preto (FCFRP), University of São Paulo (USP), Belo Horizonte, MG, Brazil ;7.Department of Pathology, ICB, UFMG, Belo Horizonte, MG, Brazil ; |
| Abstract: | Probiotics form a promising strategy to maintain intestinal health. Milks fermented with probiotic strains, such as the Lactobacillus paracasei ST11, are largely commercialized in Brazil and form a low-cost alternative to probiotic pharmaceutical formulations. In this study, we assessed the probiotic effects of milk fermented by L. paracasei ST11 (administered through fermented milk) in a Salmonella typhimurium infection model in BALB/c mice. We observed in this murine model that the applied probiotic conferred protective effects against S. typhimurium infection, since its administration reduced mortality, weight loss, translocation to target organs (liver and spleen) and ileum injury. Moreover, a reduction in the mRNA expression of pro-inflammatory cytokines such as IFN-γ, IL-6, TNF-α and IL-17 in animals that received the probiotic before challenge was observed. Additionally, the ileum microbiota was better preserved in these animals. The present study highlights a multifactorial protective aspect of this commercial probiotic strain against a common gastrointestinal pathogen. |
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