Arginine vasopressin and a vasopressin antagonist peptide: Opposite effects on extinction of active avoidance in rats |
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| Authors: | George F Koob Michel Le Moal Oedile Gaffori Maurice Manning Wilbur H Sawyer Jean Rivier Floyd E Bloom |
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| Institution: | 1. A.V. Davis Center for Behavioral Neurobiology, The Salk Institute, P.O. Box 85800, San Diego, CA 92138, U.S.A.;2. Laboratoire de Neurobilogie des Compartements, Université de Bordeaux II, F-33076 Bordeaux, France;3. Department of Biochemistry, Medical College of Ohio, Toledo, OH 43699, U.S.A.;4. Department of Pharmacology, College of Physicians, Columbia University, New York, NY 10032, U.S.A.;5. Peptide Biology Laboratory, The Salk Institute, P.O. Box 85800, San Diego, CA 92138, U.S.A. |
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| Abstract: | Systemic injection of arginine vasopressin (AVP) (1 μ/rat) significantly prolonged extinction of a pole-jump, active avoidance response in rats; lateral ventricular injection of 1000-fold less AVP (1 ng/rat) produced similar results. A new AVP analogue, 1-deaminopenicillamine-2-(O-methyl)-tyrosine]arginine vasopressin (dPTyr-(Me)AVP), is known to antagonize behavioral and vascular effects of exogenous AVP at molar ratios of 5:1. At a dose of 100 μ/rat (subcutaneously) dPTyr-(Me)AVP produces, by itself, a behavioral effect opposite to that of exogenous AVP, namely a facilitation of extinction. Injections of dPTyr-(Me)AVP into the lateral ventricle were ineffective except at a dose of 10 μg/rat. These results confirm previous reports of the effect of vasopressin on delaying extinction of avoidance behavior, but suggest a site of action distant from the lateral ventricle. |
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| Keywords: | arginine vasopressin vasopressin antagonist peptide effects extinction active avoidance |
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