A qualitative comparison of canine plasma gastroenteropancreatic hormone responses to bombesin and the porcine gastrin-releasing peptide (GRP) |
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| Authors: | TJ McDonald MA Ghatei SR Bloom NS Track J Radziuk J Dupre V Mutt |
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| Institution: | 1. Department of Medicine, University of Western Ontario, London, Ontario, Canada;2. Department of Medicine, Royal Postgraduate Medical School, London, U.K.;3. Departments of Surgery and Clinical Biochemistry, University of Toronto and Mt. Sinai Hospital, Toronto, Canada;4. Department of Biochemistry II, Karolinska Institute, Stockholm, Sweden |
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| Abstract: | The effect on plasma gastroenteropancreatic hormone levels on infusing the porcine gastrin-releasing peptide and bombesin into dogs demonstrated no qualitative difference in the spectrum of activity of the two peptides. Sustained elevations in plasma immunoreactive gastrin, pancreatic polypeptide, enteroglucagon, gastric inhibitory polypeptide, pancreatic glucagon and transient elevations in plasma insulin were seen during infusions of both peptides. The similar spectrum of activities and the structural homology between the two peptides suggests that the porcine gastrin releasing peptide is the porcine counterpart of the amphibian peptide bombesin. |
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| Keywords: | pancreatic polypeptide motilin enteroglucagon pancreatic glucagon gastrin insulin gastric inhibitory polypeptide glucose turnover |
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