New minor taxanes analogues from the needles of Taxus canadenis |
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| Authors: | Shi Qing Wen Sauriol Françoise Mamer Orval Zamir Lolita O |
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| Affiliation: | Human Health Research Center, INRS-Institut Armand-Frappier, Universite du Quebec, 531 Boulevard des Praries, Laval, Quebec, Canada H7V 1B7. |
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| Abstract: | Seven new taxanes were isolated from the needles of the Canadian yew: unusual functional groups, positions and/or stereochemical features are described. Their chemical structures were rigorously characterized by detailed high resolution NMR analyses and confirmed by high resolution Fast Atom Bombardment Mass Spectrometry. Unlike paclitaxel and taxuspine D, these taxanes had no effect on tubulin assembly. |
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