The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-alpha levels in rats |
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| Authors: | Liu Ya-Li Bi Hui Chi Su-Min Fan Rong Wang Yue-Min Ma Xin-Liang Chen Yao-Ming Luo Wen-Jing Pei Jian-Ming Chen Jing-Yuan |
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| Affiliation: | Department of Physiology, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China. yaliliu@fmmu.edu.cn |
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| Abstract: | The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders. |
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