The atrial natriuretic peptide (ANP) system in the pronephros and mesonephros of Bufo bufo larvae |
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Authors: | Simonetta Tei Sonia Salamida Daniela Vagnetti |
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Institution: | (1) Department of Cellular Environmental Biology, University of Perugia, 06123 Perugia, Italy |
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Abstract: | In this study on the excretory apparatus of the Bufo bufo larvae, the ultrastructural features and the atrial natriuretic peptide (ANP)-system were examined using cytochemical and
immunocytochemical methods. The early embryonic kidney, the pronephros, is replaced by a later stage, the mesonephros. The
pronephros degenerates at the time of metamorphosis and the mesonephros becomes the functional kidney in the adult. Both these
organs are targets for ANP, demonstrated by the presence of the specific receptors, indirectly highlighted by the cytochemical
localization of the guanylate cyclase in the presence of exogenous atrial natriuretic peptide. This study concluded that the
mesonephros produces ANP and thus clusters of cells containing ANP-like granules, positive to the anti-α ANP immunolocalization,
were present along the mesonephric proximal tubule. The atrial natriuretic peptide system carries out an important osmoregulatory
role in the excretory apparatus. |
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Keywords: | Bufo bufo larvae pronephros mesonephros atrial natriuretic peptide ultrastructure cytochemistry immunocytochemistry |
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