Regulation of Chloride Channels in Secretory Epithelia |
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| Authors: | T Begenisich JE Melvin |
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| Institution: | (1) Rochester Institute of Biomedical Sciences, Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA, US;(2) Rochester Institute of Biomedical Sciences, the Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA, US |
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| Abstract: | Fluid and electrolyte secretion from secretory epithelia is a highly regulated process. Chloride channel activity at the
apical membrane determines the rate and direction of salt and water secretion. Multiple classes of Cl− channels with distinct gating mechanisms are involved in moving ions and water. Secretory agonists that induce intracellular
increases in two second messenger systems, cAMP and Ca2+]
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, are generally associated with secretion. However, changes in cell volume and the membrane potential may also play a role
in regulating fluid and electrolyte secretion in some tissues. In this review we discuss the regulation of the different types
of Cl− channels found in secretory epithelia.
Received: 16 September 1997/Revised: 13 November 1997 |
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| Keywords: | : Secretion — Regulation — cAMP-activated Cl− channel — Volume-sensitive Cl− channel — Voltage-gated Cl− channel — Ca2+-dependent Cl− channel |
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