Nucleotide sequence of the gene encoding the active-site serine β-lactamase from Actinomadura R39 |
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| Authors: | Simone Houba,Sabine Willem,Colette Duez,Chantal Molitor,Jean Dusart,Jean-Marie Frè re,Jean-Marie Ghuysen |
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| Affiliation: | Service de Microbiologie, Université de Liège, Institut de Chimie, Sart Tilman, Belgium. |
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| Abstract: | The gene encoding the extracellular, active-site serine beta-lactamase of Actinomadura R39, previously cloned into Streptomyces lividans, has the information for the synthesis of a 304 amino acid protein, the amino terminal region of which has the characteristic features of a signal peptide. The Actinomadura R39 beta-lactamase is another member of the class A beta-lactamases. In particular, it shows high homology with the beta-lactamase of Bacillus licheniformis. |
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