N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists |
| |
Authors: | Doherty George A Kamenecka Theodore McCauley Ermenegilda Van Riper Gail Mumford Richard A Tong Sharon Hagmann William K |
| |
Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. george_doherty@merck.com |
| |
Abstract: | A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|