N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists |
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| Authors: | Doherty George A Kamenecka Theodore McCauley Ermenegilda Van Riper Gail Mumford Richard A Tong Sharon Hagmann William K |
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| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. george_doherty@merck.com |
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| Abstract: | A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4. |
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