| Abstract: | Nowadays, because of increasing employment of swine for experimental studies and medicaltraining, it is hopeful to investigate novel and effective anaesthetic protocols forpreserving the animal welfare in medical investigation and concurrently improving thequality of research. Therefore, the aim of this study was to investigate a novel andeffective anaesthetic protocol in swine undergoing major surgery, by translating know-howof combined anaesthesia from human protocols. Seven landrace swine were anaesthetized forthree hours by a combined trial anaesthetic protocol (sedation: medetomidine,acepromazine, atropine and tramadol; induction: propofol, medetomidine and acepromazine;anaesthesia: isofluorane, propofol, medetomidine and acepromazine) and both clinical andhaemodynamic parameters were compared with those of five swine anaesthetized with acontrol protocol (sedation: diazepam, ketamine and atropina; induction: diazepam andketamine; anaesthesia: isofluorane). Both cardiac frequency (CF) and mean blood pressure(MBP) were significantly (P<0.05) more stable in trial protocol (CF:78.3 ± 4.6-81.1 ± 5, MBP: 63.9 ± 10.7-96.4 ± 13.0) compared to control protocol (CF: 93.7± 5.5-102.5 ± 8.5, MBP: 71.0 ± 6.6-108.7 ± 7.2). The body temperature remained stable intrial protocol (°C: 36.9 ± 0.7-37.2 ± 0.3) compared to control anaesthesia (°C: 36.4 ±0.3-37.3 ± 0.2, P<0.05). Haematosis improved undergoing combinedanaesthesia (+2%, P<0.05) whereas did not change in control animals.There were no differences in respiratory rate between trial and control protocols. Thisstudy demonstrates that the proposed balanced intravenous-inhalant protocol permits tocarry out a very effective, stable and safe anaesthesia in swine undergoing deepanaesthesia. |
