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VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage
Affiliation:1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;2. Department of Chemical & Petroleum Engineering and Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045, USA;3. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA;4. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA;5. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;6. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892, USA
Abstract:
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  • Keywords:antibody sequencing  antibody maturation  B cell ontogeny  broadly neutralizing antibody  fusion peptide-directed  rare mutations  somatic hypermutation  SHM
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