Knockout of the folate transporter <Emphasis Type="Italic">folt-1</Emphasis> causes germline and somatic defects in <Emphasis Type="Italic">C. elegans</Emphasis> |
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| Authors: | Misa U Austin Wei-Siang Liau Krishnaswamy Balamurugan Balasubramaniem Ashokkumar Hamid M Said Craig W LaMunyon |
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| Institution: | (1) Department of Biological Sciences, California State University Pomona, CA 91768, USA;(2) Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA;(3) Veterans Affairs Medical Center, Long Beach, CA 90822, USA;(4) Departments of Medicine and Physiology/Biophysics, University of California, Irvine, CA 92697, USA;(5) Department of Biotechnology, Alagappa University, Karaikudi, 630 003, India |
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| Abstract: | Background The C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be
involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the source of the sterility and the effect of the folt-1 knockout on somatic function. |
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