Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs |
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| Authors: | H C Lin G F Liu A G Wang L J Kong X F Wang J L Fu |
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| Institution: | (1) College of Animal Science and Technology & Key Laboratory for Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, 100193 Beijing, China;(2) Institute of Animal Science and Veterinary Medicine Shandong Academy of Agricultural Sciences, 250100 Jinan, China |
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| Abstract: | DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter
size in Large White pigs. A total of 2,167 litter records from 420 sows genotyped at two SNP loci (LIF1 and LIF2) within LIF
gene were analyzed to determine whether LIF influenced total number born (TNB) and number born alive (NBA). The results indicated
that B allele at LIF1 locus and A allele at LIF2 locus seem to have advantageous effects on litter size. However, the combined
analyzed results demonstrated that genotype AAAA, ABBB, and BBBB are better than genotype AAAB, AABB, and ABAB for TNB and
NBA in either third to eighth parity or all parities. In all parities, the sows with AAAA genotype had an advantage of 1.76
piglets (P < 0.001) for TNB and 1.44 piglets (P < 0.01) for NBA per litter over the AAAB sows, respectively. The results in this study demonstrated that LIF gene was significantly
associated with litter size in pigs.
H. C. Lin and G. F. Liu contributed equally to this work. |
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| Keywords: | Candidate gene Leukemia inhibitory factor Litter size Pig Reproduction |
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