Macroscopic Ca2+ -Na+ and K+ currents in single heart and aortic cells |
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Authors: | G Bkaily M Peyrow T Yamamoto A Sculptoreanu D Jacques N Sperelakis |
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Institution: | (1) Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke (CHUS), J1H 5N4 Sherbrooke, Québec, Canada;(2) Department of Physiology and Biophysics, School of Medicine, University of Cincinnati, Cincinnati, Ohio, USA |
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Abstract: | Summary The whole-cell voltage clamp technique was used to study the slow inward currents and K+ outward currents in single heart cells of embryonic chick and in rabbit aortic cells. In single heart cells of 3-day-old chick embryo three types of slow inward Na+ currents were found. The kinetics and the pharmacology of the slow INa, were different from those of the slow Ica in older embryos. Two types of slow inward currents were found in aortic single cells of rabbit; angiotensin 11 increased the sustained type and d-cAMP and d-cGMP decreased the slow transient component. Two types of outward K+ currents were found in both aortic and heart cells. Single channel analysis demonstrated the presence of a high single K+ channel conductance in aortic cells. In cardiac and vascular smooth muscles, slow inward currents do share some pharmacological properties, although the regulation of these channels by cyclic nucleotides and several drugs seems to be different. |
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Keywords: | heart cells aortic cells Ca2- current K+ current slow Na+ current Angiotensin II calcium blockers potassium blockers patch clamp |
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