| 磁休克治疗对重度抑郁症患者脑功能网络的影响 |
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| 引用本文： | 田树香,徐桂芝,王龙龙,刘向向,FITZGERALD B Paul. 磁休克治疗对重度抑郁症患者脑功能网络的影响[J]. 生物化学与生物物理进展, 2022, 49(6): 1103-1113 |
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| 作者姓名： | 田树香 徐桂芝 王龙龙 刘向向 FITZGERALD B Paul |
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| 作者单位： | 1）河北工业大学电气工程学院，省部共建电工装备可靠性与智能化国家重点实验室，天津 310130;2）河北工业大学电气工程学院，河北省生物电磁与神经工程重点实验室，天津 310130,1）河北工业大学电气工程学院，省部共建电工装备可靠性与智能化国家重点实验室，天津 310130;2）河北工业大学电气工程学院，河北省生物电磁与神经工程重点实验室，天津 310130,1）河北工业大学电气工程学院，省部共建电工装备可靠性与智能化国家重点实验室，天津 310130;2）河北工业大学电气工程学院，河北省生物电磁与神经工程重点实验室，天津 310130,1）河北工业大学电气工程学院，省部共建电工装备可靠性与智能化国家重点实验室，天津 310130,3）Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Monash Alfred Psychiatry Research Centre, Monash University, Melbourne 3004, Australia |
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| 基金项目： | 国家自然科学基金（51737003），国家留学基金（201806700011） 和河北工业大学海外联合培养基金（2017HW007） 资助项目。 |
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| 摘 要： | 目的 磁休克治疗(MST)是一种新兴的神经调节干预技术,在重度抑郁症(MDD)治疗中得到广泛应用,然而其抗抑郁机制尚不清楚。探索MST对不同疗效MDD患者脑功能网络的调控作用,对MST治疗的抗抑郁作用机制研究具有重要意义。方法 本文对18例MDD患者MST作用前后的静息态脑电进行记录,基于皮尔逊相关方法构建脑功能网络;应用复杂网络理论对比分析脑功能网络拓扑结构的改变;根据HDRS-17评分变化率进一步区分治疗有效组和无效组,对网络特征进行二次比较。结果 MST后,MDD患者的脑功能网络平均节点度、平均聚类系数和平均全局效率值均比治疗前显著升高,平均路径长度值显著降低,小世界属性显著增大;相比于治疗无效组,治疗有效组的脑功能网络特征参数变化量更大。结论 MST显著改变了MDD患者脑功能网络拓扑结构,对患者的脑功能网络具有一定的调制作用,这些结果为MST治疗的抗抑郁机制研究提供了实验支持和理论依据。
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| 关 键 词： | 重度抑郁症 磁休克治疗 静息态脑电 脑功能网络 |
| 收稿时间： | 2022-01-12 |
| 修稿时间： | 2022-03-16 |
The Effects of Magnetic Seizure Therapy on Brain Functional Network in Major Depressive Disorder |
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| TIAN Shu-Xiang,XU Gui-Zhi,WANG Long-Long,LIU Xiang-Xiang and FITZGERALD B Paul. The Effects of Magnetic Seizure Therapy on Brain Functional Network in Major Depressive Disorder[J]. Progress In Biochemistry and Biophysics, 2022, 49(6): 1103-1113 |
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| Authors: | TIAN Shu-Xiang XU Gui-Zhi WANG Long-Long LIU Xiang-Xiang FITZGERALD B Paul |
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| Affiliation: | 1)State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China;2)Key Laboratory of Bioelectromagnetic and Neural Engineering of Hebei Province, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China,1)State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China;2)Key Laboratory of Bioelectromagnetic and Neural Engineering of Hebei Province, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China,1)State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China;2)Key Laboratory of Bioelectromagnetic and Neural Engineering of Hebei Province, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China,1)State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China,3)Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Monash Alfred Psychiatry Research Centre, Monash University, Melbourne 3004, Australia |
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| Abstract: | Objective Magnetic seizure therapy (MST) is an emerging neuromodulation intervention technique that is widely used in the treatment of major depressive disorder (MDD), but its antidepressant mechanism is still unclear. Therefore, exploring the regulatory effect of MST on the brain functional network of MDD patients with different therapeutic effects is of great significance for the study of the antidepressant mechanism of MST treatment.Methods In this study, the resting-state EEG of 18 MDD patients pre- and post-MST was recorded, and the Pearson correlation method was used to construct the brain functional network; the complex network theory was used to compare and analyze the changes in the topology of the brain functional network; according to the rate of change of the HDRS-17 score, it was further distinguished. The network characteristics were performed a secondary comparison between responders and non-responders.Results The brain functional network connectivity, mean node degree, mean clustering coefficient, and mean global efficiency values were significantly higher than that pre-MST treatment. Mean path length values were significantly lower, and small world attribute significantly increased post-MST treatment. Compared with the group of non-responders, the changes in the characteristic parameters of the brain functional network in the group of responders were significantly larger.Conclusion MST significantly changes the topology of the brain functional network in patients with MDD, and it has a certain modulation effect on the brain functional network of patients. These results provide experimental support and a theoretical basis for the study of the antidepressant mechanism of MST treatment. |
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| Keywords: | major depressive disorder magnetic seizure therapy resting-state EEG functional brain network |
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