Structure for Hyaluronic Acid |
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Authors: | E D T ATKINS J K SHEEHAN |
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Institution: | 1.H. H. Wills Physics Laboratory,University of Bristol,Bristol |
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Abstract: | THE mucopolysaccharide hyaluronic acid exists naturally as a hydrated gel. It is the constituent of synovial fluid which acts as a lubricant; it also occurs in the vitreous humour where its function is probably to maintain the precise shape of the eye. Chemically it is a regular, unbranched polymer with a repeating unit of the type (-N-G-)n where N is N-acetylglucosamine and G is glucuronic acid. The glycosidic linkages N to G and G to N are 1e, 4e and le, 3e respectively (Fig. 1). Our arguments are based on the postulate that both glucopyranose rings are in the C1 chain conformation. |
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