Response of two strains of L5178Y cells to cis-dichlorobis(cyclopentylamine)platinum(II). II. Differential effects of caffeine. |
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Authors: | I Szumiel |
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Institution: | Department of Radiobiology and Health Protection, Institute of Nuclear Research Dorodna 16, OS-195 Warsaw Poland |
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Abstract: | Two strains of L5178Y murine lymphoma, inversely cross-sensitive to X-rays and UV light, were shown previously to respond to treatment with an antitumour platinum complex, cis-dichlorobis(cyclopentylamine)-platinum(II) (cis-PAD), in a similar manner as to UV. Enhancement of chromosomal damage and potentiation of lethal effect of cis-PAD by 0.75 mM caffeine were found in cis-PAD and UV light-resistant L5178Y-S strain but not in cis-PAD and UV light-sensitive L5178Y-R strain. These results suggest that the extreme sensitivity of L5178Y-R strain to cis-PAD and UV light is caused to some extent by deficiency in a caffeine-sensitive post-replication repair system. |
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Keywords: | DMSO dimethyl-sulphoxide |
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