Potassium-stimulated release of GABA,glycine, and taurine from the chick retina |
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Authors: | A M López-Colomé R Salceda H Pasantes-Morales |
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Institution: | (1) Departamento de Biología Experimental, Instituto de Biología, Universidad Nacional Autónoma de México, Apartado Postal 70-6000, México 20, D.F., México |
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Abstract: | The effect of depolarizing potassium concentration on the release of 14C]glycine, 3H]GABA, and 35S]taurine was investigated in the whole chick retina and in a synaptosomal fraction prepared from the chick retina. In the whole retina, increasing potassium concentration above 40 mM resulted in an increased release of the three amino acids. The release of glycine was the most stimulated and that of taurine, the least. The potassium-evoked release of glycine and GABA was calcium dependent. In the synaptosomal fraction, 68.5 mM potassium significantly stimulated the efflux of GABA and glycine by a calcium-dependent mechanism. The release of taurine from this fraction was unaffected by high potassium. |
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