首页 | 本学科首页   官方微博 | 高级检索  
     


The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease
Authors:Bengt Fadeel
Affiliation:1. Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Swedenbengt.fadeel@ki.se
Abstract:A common feature of all eukaryotic membranes is the non-random distribution of different lipid species in the lipid bilayer (lipid asymmetry). Lipid asymmetry provides the two sides of the plasma membrane with different biophysical properties and influences numerous cellular functions. Alteration of lipid asymmetry plays a prominent role during cell fusion, activation of the coagulation cascade, and recognition and removal of apoptotic cell corpses by macrophages (programmed cell clearance). Here we discuss the origin and maintenance of phospholipid asymmetry, based on recent studies in mammalian systems as well as in Caenhorhabditis elegans and other model organisms, along with emerging evidence for a conserved role of mitochondria in the loss of lipid asymmetry during apoptosis. The functional significance of lipid asymmetry and its disruption during health and disease is also discussed.
Keywords:Phospholipid asymmetry  Caenhorhabditis elegans  programmed cell clearance  mitochondria  phosphatidylserine  phospholipid scramblases  aminophospholipid translocases
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号