Whither Goest the RGS Proteins? |
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Authors: | David P Siderovski Bentley Strockbine Cynthia I Behe |
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Institution: | Department of Pharmacology, School of Medicine, The University of North Carolina at Chapel Hill, Campus Box #7365, Mary Ellen Jones Building, Room 906B, Chapel Hill, NC 27599-7365 |
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Abstract: | Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits — the “regulator of G protein signaling” or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D-AKAP2, the G protein-coupled receptor kinases GRKs], the DEP/GGL/RGS subfamily RGS6, RGS7, RGS9, RGS11], and RGS12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators. |
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Keywords: | desensitization effector proteins GGL GoLoco PDZ PTB regulators of G protein signaling RGS scaffold proteins signal transduction |
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