| Abstract: | Exocellular phosphomannans produced by four strains of Hansenula yeast were examined as to their interferon-inducing activities in rabbits employing the assay system consisting of vesicular stomatitis virus and primary suckling rabbit kidney cells. The phosphomannan of Hansenula holstii NRRL Y-2155 was shown to be the most potent inducer, and the interferon induced was highly host species-specific, preventing viral cytopathic effects only in the homologous cells. The biological and chemical characteristics of the interferon closely resembled those of endotoxin-induced interferon. |
