Metals ions and neurodegeneration |
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| Authors: | Francisco Molina-Holgado Robert C. Hider Alessandra Gaeta Robert Williams Paul Francis |
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| Affiliation: | (1) Wolfson Centre for Age Related Diseases, King’s College, London, UK;(2) Division of Pharmaceutical Science, King’s College, London, UK |
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| Abstract: | Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer’s disease and Parkinson’s disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration. |
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| Keywords: | Neurodegeneration Protein aggregation Oxidative stress Aβ -amyloid α -Synuclein Chelation therapy Iron |
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