Effect of methylmercuric chloride (MMC) on fibrin polymerization |
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| Authors: | Marta Michalska Ryszard Wierzbicki |
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| Institution: | (1) Insitute of Environmental Research and Bioanalysis, Department of Biochemistry, Medical University, Muszyńskiego 1, 90-151 Lódż, Poland |
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| Abstract: | Methylmercuric chloride (MMC) in concentrations 0.1–10μM reduces the amount of fibrinopeptides released from thrombinactivated human fibrinogen. However, the fibrin clot formation
is not discriminated and the turbidity of the fibrin gel is even augmented. MMC does not cause such changes in the process
of repolymerization of fibrin monomers. The addition of fibrinopeptides to the fibrin monomers results in a similar increase
of turbidity of the repolymerizing sample in the presence of MMC as in the case of fibrinogen clotting. These experiments
indicate that MMC modifies the structure of fibrin in the presence of fibrinopeptides. |
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| Keywords: | Methylmercuric chloride fibrin fibrinopeptides fibrin polymerization |
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