The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria |
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| Authors: | Gey Van Pittius N C Gamieldien J Hide W Brown G D Siezen R J Beyers A D |
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| Institution: | (1) Department of Medical Biochemistry, US/MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, 7505, South Africa;(2) South African National Bioinformatics Institute (SANBI), University of the Western Cape, Bellville, 7535, South Africa;(3) Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK;(4) Center for Molecular and Biomolecular Informatics, University of Nijmegen, 6525ED Nijmegen, The Netherlands |
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| Abstract: | Background The genome of Mycobacterium tuberculosis H37Rv has five copies of a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 (lhp) and ESAT-6 (esat-6) gene families (encoding secreted T-cell antigens that lack detectable secretion signals) as well as genes encoding secreted, cell-wall-associated subtilisin-like serine proteases, putative ABC transporters, ATP-binding proteins and other membrane-associated proteins. These membrane-associated and energy-providing proteins may function to secrete members of the ESAT-6 and CFP-10 protein families, and the proteases may be involved in processing the secreted peptide. |
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