睡眠研究中相关动物选择的进展

在睡眠研究使用的各种实验动物中,除了常用的啮齿类动物,还有猫、果蝇、猴和斑马鱼等.啮齿类动物因制作其睡眠相关的模型简便易行而得到广泛的应用,主要是采用各种物理化学方法制作失眠动物模型；转基因小鼠主要应用于药物干预睡眠及睡眠发生机制的研究；果蝇和斑马鱼多用于遗传学中睡眠的研究；猫用于睡眠研究的历史悠久,多用于体内试验,对内源性神经递质进行定量分析;猴睡眠结构与人相似,被广泛用于神经生物学,行为药理学等领域与睡眠的关系研究中.由于各种实验动物特殊的生理特征,在睡眠研究中多根据研究目的选择不同的实验动物.

Progress in the animal selection for sleep research

Besides commonly used rodents,there are a variety of experimental animals involved in the study of sleep,including cat,drosophila,monkey,zebrafish and so on.Rodents are used widely in sleep studies,because it is easy to make sleep models on rodents by physical and chemical methods.Among them,transgenic mice are mainly used for drug development and of sleep mechanism study.Drosophila and zebrafish are usually applied to genetic studies of sleep.Using cats for sleep study has a long history,and they are now often used to quantify in vivo endogenous neurotransmitters.Monkeys have a similar sleep structure to humans,so that they are widely used to study the relationship between sleep and neurobiology,behavioral pharmacology and so on.Animals are selected for experiments on the basis of research purpose,because each kind of animals has its own unique physiological characteristics.