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Development of Neurological Disease Is Associated with Increased Immune Activation in Simian Immunodeficiency Virus-Infected Macaques |
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| Authors: | Que Dang Sonya Whitted Robert M. Goeken Jason M. Brenchley Kenta Matsuda Charles R. Brown Bernard A. P. Lafont Matthew F. Starost Ranjini Iyengar Ronald J. Plishka Alicia Buckler-White Vanessa M. Hirsch |
| Affiliation: | aLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA;bDivision of Veterinary Resources, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA |
| Abstract: | Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease. |
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