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Staphylococcus aureus CC398 Clade Associated with Human-to-Human Transmission
Authors:Alex J McCarthy  Willem van Wamel  Stien Vandendriessche  Jesper Larsen  Olivier Denis  Cristina Garcia-Graells  Ann-Catrin Uhlemann  Franklin D Lowy  Robert Skov  Jodi A Lindsay
Abstract:Staphylococcus aureus clonal complex 398 (CC398) isolates colonize livestock and can spread to human contacts. Genetic analysis of isolates epidemiologically associated with human-to-human, but not livestock, transmission in multiple countries and continents identified a common clade that was negative for tet(M) and positive for bacteriophage ϕ3. Another group of human-to-human-transmitted isolates belonged to the common livestock-associated clade but had acquired a unique ϕ7 bacteriophage.
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