Gender- and age-related outcomes of cardiac resynchronization therapy: A pilot observational study

Background: Cardiac re synchronization therapy (CRT) has been reported to improve clinical status and survival, and shorten hospitalization rates, in patients with heart failure (HF). However, questions remain regarding the success of CRT in different subgroups of patients with HEObjective: We assessed whether CRT response was related to gender or age in patients with HE.Methods: In a longitudinal observational study, patients with severe HF (New York Heart Association [NYHA] class III or IV, left ventricular ejection fraction [LVEF] ≤35%, and QRS duration >120 ms with left bundle branch block configuration) were enrolled. Clinical electrophysiologic and echocardiographic evaluations were performed before, and 3 and 6 months after, CRT implantation.Results: A total of 65 Iranian patients (50 men, 15 women; mean [SD] age, 60.3 [10.3] years; baseline NYHA class, 3.1 [0.36]; QRS duration, 144 [14] ms; LVEF, 21% [7.3%]; left ventricular end-diastolic diameter (LVEDD), 6.8 [0.56] mm) were evaluated. NYHA class, QRS duration, LVEF, and LVEDD were significantly improved at 3- and 6-month follow-ups both in patients aged ≤60 years and in those aged >60 years (P < 0.001, except for aged ≤60 years after 3-month follow-up [P = 0.002]). All these parameters were significantly improved in men at 3- and 6-month follow-ups (P < 0.001). NYHA class (P = 0.002), QRS duration (P = 0.001), LVEF (P = 0.013 at 3 months and <0.001 at 6 months), and LVEDD (P = 0.007 at 3 months and <0.001 at 6 months) also were significantly improved in women. At 3- and 6-month follow-ups, there were no significant differences in improvement of these factors between the 2 age groups of patients.Conclusion: CRT response in these patients with HF did not appear to be gender or age related at 3- and 6-month follow-ups in this small observational study. Confirmation of these findings by larger studies is needed.