Genomic and Phylogenetic Characterization of Brazilian Yellow Fever Virus Strains |
| |
| Authors: | Marcio R T Nunes Gustavo Palacios Jedson F Cardoso Livia C Martins Edivaldo C Sousa Jr Clayton P S de Lima Daniele B A Medeiros Nazir Savji Aaloki Desai Sueli G Rodrigues Valeria L Carvalho W Ian Lipkin Pedro F C Vasconcelos |
| |
| Institution: | aCenter for Technological Innovation, Instituto Evandro Chagas, Ananindeua, Brazil;bColumbia University, New York, New York, USA;cDepartamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Brazil;dUniversidade do Estado do Pará, Belém, Brazil |
| |
| Abstract: | Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3′ noncoding region (3′NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon. |
| |
| Keywords: | |
|
|
