Stimulation of indirubin production by KNO3 depletion in indole-supplemented suspension culture of Polygonum tinctorium |
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| Authors: | Chung I S Kim T Bae G W Lee H J Chae Y A |
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| Institution: | (1) Department of Genetic Engineering, Kyung Hee University, 449-701 Suwon, Korea;(2) RCNBMA, Seoul National University, 441-744 Suwon, Korea |
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| Abstract: | Summary Indole when added at 20 mM to shake flask cultures of Polygonum tinctorium cells on 16th day increased indirubin production from 41 mg/l to 126 mg/l. Use of KNO3 depleted media stimulated indirubin formation up to 88% and 26% in shake flasks and air-lift bioreactors, respectively. |
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