The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review |
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Authors: | Esteban Domingo Encarnación Martínez-Salas Francisco Sobrino Juan Carlos de la Torre Agustín Portela Juan Ortín Cecilio López-Galindez Pilar Pérez-Breña Nieves Villanueva Rafael Nájera Scott VandePol David Steinhauer Nicholas DePolo John Holland |
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Affiliation: | 1. Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma, Canto Blanco, 28049 MadridSpain Tel. 7349300, ext. 225;2. Centro Nacional de Microbioiogia Virología e Inmunología Sanitarias, Majadahonda, MadridSpain Tel. 6380299;3. Department of Biology University of California at San Diego, La Jolla, CA 92093 U.S.A. Tel. (619)452-2520 |
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Abstract: | We review evidence that cloned (or uncloned) populations of most RNA viruses do not consist of a single genome species of defined sequence, but rather of heterogeneous mixtures of related genomes (quasispecies). Due to very high mutation rates, genomes of a quasispecies virus population share a consensus sequence but differ from each other and from the consensus sequence by one, several, or many mutations. Viral genome analyses by sequencing, fingerprinting, cDNA cloning etc. indicate that most viral RNA populations (quasispecies) contain all possible single and double genomic site mutations and varying proportions of triple, quadruple, etc. site mutations. This quasispecies structure of RNA virus populations has many important theoretical and practical implications because mutations at only one or a few sites may alter the phenotype of an RNA virus. |
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Keywords: | Genetic heterogeneity recombinant DNA molecular epidemiology virus disease evolution mutation aa amino acid(s) AIDS acquired immune deficiency syndrome DI defective interfering FMDV foot-and-mouth disease virus HTLV human T-cell lymphotropic virus InV influenza virus kb kilobases or kilobase pairs p.i. postinfection nt nucleotide(s) pfu plaque-forming units TMV tobacco mosaic virus VSV vesicular stomatitis virus |
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