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Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease
Authors:Radu Dobrin  Jun Zhu  Cliona Molony  Carmen Argman  Mark L Parrish  Sonia Carlson  Mark F Allan  Daniel Pomp  Eric E Schadt
Institution:(1) Rosetta Inpharmatics, LLC, Merck & Co., Inc., Terry Avenue North, Seattle, Washington 98109, USA;(2) Department of Animal Science, University of Nebraska, Lincoln, NE 68508, USA;(3) Department of Nutrition, Cell and Molecular Physiology, Carolina Center for Genome Science, University of North Carolina, Chapel Hill, NC 27599, USA;(4) Current address: Pfizer Animal Health, Animal Genetics Business Unit, East 42nd Street, New York, NY 10017, USA;(5) Current address: Pacific Biosciences, 1505 Adams Dr, Menlo Park, CA 94025, USA
Abstract:

Background  

Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic tissues, resulting in an energy imbalance at the systems level.
Keywords:
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