Synthesis of novel 2'-deoxy type trans-3',4'-bridged nucleic acid |
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| Authors: | Osaki Tomohisa Obika Satoshi Harada Yasuki Mitsuoka Yasunori Sugaya Kensaku Sekiguchi Mitsuaki Roongjang Somjing Imanishi Takeshi |
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| Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan. |
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| Abstract: | We newly designed and synthesized a 2'-deoxy type trans-3',4'-bridged nucleic acid (trans-3',4'-BNA) analogues bearing a 4,7-dioxabicyclo4.3.0]nonane structure. The synthesis of the trans-3',4'-BNA was carried out successfully from thymidine over 21 steps. The structure of trans-3',4'-BNA was confirmed by x-ray crystallographic analysis, indicating that the furanose ring has a typical S-type conformation with C(3')-exo puckering. |
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