Circulating immune complexes in cerebrospinal fluid of patients with tuberculous meningitis. |
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| Authors: | A Mathai V V Radhakrishnan S Sehgal |
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| Institution: | Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. |
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| Abstract: | Circulating immune complexes (ICs) were isolated from cerebrospinal fluids (CSFs) of patients with tuberculous meningitis (TBM), non-tuberculous neurological diseases by a polyethylene glycol (PEG) precipitation method. Mycobacterium tuberculosis antigen 5 was detected in CICs of 30% patients with TBM, by sandwich ELISA. CIC level decreases during antituberculosis chemotherapy and therefore its detection can provide a method to monitor the therapeutic schedule in patients with TBM. |
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