Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population |
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Authors: | Kim Won Hee Min Kyung Tae Jeon Young Joo Kwon Chang-Il Ko Kwang Hyun Park Pil Won Hong Sung Pyo Rim Kyu Seong Kwon Sung Won Hwang Seong Gyu Kim Nam Keun |
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Institution: | Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea. |
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Abstract: | BackgroundRecent studies have suggested that common genetic polymorphisms alter the processing of microRNA (miRNA) and may be associated with the development and progression of cancer.Patients and methodsThe association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.ResultsThe risk of HCC was significantly lower for the miR-499A>G, AG + GG in HCC patients (AOR = 0.603, 95% CI = 0.370–0.984) and hepatitis B virus (HBV)-related HCC patients (AOR = 0.561, 95% CI 0.331–0.950). In addition, the risk of HCC was significantly lower for the miR-149C>T, CT and CT + CC in HCC patients (CT; AOR = 0.542, 95% CI = 0.332–0.886, CT + CC; AOR = 0.536, 95% CI = 0.335–0.858) and HBV-related HCC patients (CT: AOR = 0.510, 95% CI 0.305–0.854, CT + CC: AOR = 0.496, 95% CI 0.302–0.813). The miR-149C>T polymorphism was also associated with survival rate of HCC patients in OKUDA II stage.ConclusionsmiR-149C>T and miR-499A>G were associated with HBV-related HCC. Further studies on larger populations will need to be conducted to confirm these results. |
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Keywords: | miRNA microRNA pri-miRNA primary miRNA pre-miRNA premature miRNA HCC hepatocellular carcinoma SNP single nucleotide polymorphism OR odds ratio CI confidence interval |
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