Formation and Reactivity of 2,4-Ditriazolyl Pyrimidine C-Nucleoside Derived from Pseudouridine |
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| Authors: | Natalia Dyatkina Alexander Khorlin Kyoichi A. Watanabe |
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| Affiliation: | 1. Codon Pharmaceuticals, Inc. , 200 Perry Parkway, Gaithersburg, MD, 20877;2. Genelabs Technologies, Inc. , 505 Penobscot Drive, Redwood City, CA, 94063;3. Pharmasset, Inc. , 1860 Montreal Road, Tucker, GA, 30084 |
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| Abstract: | Abstract Thymine and 2′,3′,5′-tri-O-acetyl-Ψ-uridine (1) was converted into the corresponding 2,4-ditriazolyl derivatives 5 and 2, respectively. Of these two substituents, the C4-triazolyl group was found to be quite susceptible to nucleophilic substitution while the other triazolyl is resistant. |
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