Synthesis and Antiviral Activity of Some C2-, C4-, and C6-Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV,HBG, and ISO-DHPG |
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Authors: | Omar Moukha-chafiq Mohamed Labd Taha Hassan Bihi Lazrek Jean-Jacques Vasseur Erik De Clercq |
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Affiliation: | 1. Laboratoire de Chimie Bio-Organique, Faculte des Sciences , Agadir, Maroc;2. Laboratoire de Chimie Bio-Organique, Faculte des Sciences I , Marrakech, Maroc;3. Lab. de Chimie Organique Biomoleculaire de synthèse , U.S.T. Montpellier II , Moukhao, Montpellier, France;4. Rega Institute for Medical Research, Katholieke Universiteit Leuven , Leuven, Belgium |
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Abstract: | A useful route to obtain trisubstituted pyrazolo[3,4-d]pyrimidines 14–17 is described. Those later were coupled with the alkylating agents 18–20 as in ACV, HBG, and iso-DHPG to give, after deprotection, the desired acylonucleosides 33–44. Almost all of the new compounds were evaluated for their inhibitory effects against the replication of various DNA viruses in culture. |
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Keywords: | C2-, C4-, and C6-substituted pyrazolo[3,4-d]pyrimidines Acyclonucleoside Analogues of ACV, HBG, and iso-DHPG |
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