Metabolism of O6-Propyl and N6-Propyl-carbovir in CEM Cells |
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| Authors: | William B Parker Sue C Shaddix Lucy M Rose Phuong T Pham Mei Hua Robert Vince |
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| Institution: | 1. Southern Research Institute , 2000 Ninth Avenue South, Birmingham, AL, 35205, USA;2. Department of Medicinal Chemistry , College of Pharmacy, University of Minnesota , Minneapolis, MN, 55455, USA |
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| Abstract: | Abstract The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5′-triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3-nonyl)adenine. No evidence of the 5′-triphosphate of either compound was detected in CEM cells. |
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