Synthesis of N6-Substituted 9-[3-(Phosphonomethoxy)Propyl]Adenine Derivatives As Possible Antiviral Agents |
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| Authors: | Yahya El-Kattan Tsu-Hsing Lin Minwan Wu V. Satish Kumar Pravin L. Kotian Ajit Ghosh |
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| Affiliation: | BioCryst Pharmaceuticals, Inc. , Birmingham, Alabama, USA |
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| Abstract: | A number of N 6 -substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives having hydroxymethyl at C-1′-position were prepared from the appropriate 6-chloroadenine derivative. The syntheses of the corresponding prodrugs of these compounds are also reported. These compounds showed poor activity against HCV in replicon assay. |
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| Keywords: | Acyclic nucleosides Prodrugs Antiviral |
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