Synthesis,Characterization, and Evaluation of Five Coordinated Copper(II) Complexes as Antibacterial,Artificial Nuclease,and Sod Mimics |
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| Authors: | M N Patel D S Gandhi P A Parmar |
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| Institution: | Department of Chemistry , Sardar Patel University , Vallabh Vidyanagar , Gujarat , India |
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| Abstract: | The copper(II) complexes with ciprofloxacin (CFLH), levofloxacin (LFLH), norfloxacin (NFLH), and neutral bidentate ligands have been synthesized and characterized. The complexes have been evaluated for their antibacterial activity against selective species. Complexes have been also checked for their interacting behavior with DNA, and were found to have two different modes of interaction, classical and partial intercalation. Tested complexes were found to be better antioxidants with their IC50 values ranging from 0.51 to 0.97 μM. |
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| Keywords: | Square pyramidal Cu(II) complexes fluoroquinolone MIC intercalation mode of binding |
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